And like it's previous three contests, OU jumped out to an early 1-0 lead and squandered several opportunities to make it worse than that.
The Sooners managed just one run after loading the bases in the first inning and failed to add to it in the second when they again had the sacks full with nobody out.
"I mean, most of all it's just baseball," said shortstop Caleb Bushyhead. "That's just kind of how it goes."
Texas took advantage of OU's inability to convert by adding two in the top of the third.
Third baseman Erich Weiss tripled to right center, plating right fielder Mark Payton, and scored moments later on a wild pitch.
The Longhorns added two more in the fourth to make it 4-1 when shortstop Jordan Etier ripped a two-run triple to right center.
OU notched things back up in the bottom half, as center fielder Erik Ross singled to right and brought home right fielder Cody Reine.
First baseman Max White followed up with a two-run single, scoring Ross and catcher Tanner Toal.
But from there, it was all Texas.
The Longhorns scored one in the fifth, one in the sixth, two in the seventh and one in the eighth to open up a 9-5 lead.
"That's the best hitting club we've seen all year beyond the shadow of a doubt," said OU head coach Sunny Golloway. "They'll outhit Oregon, Oregon State. That's the best hitting club we've seen."
OU's only other run came in the bottom of the seventh when third baseman Garrett Carey hit home designated hitter Evan Mistich on a sacrifice fly to left.
The main stories of the game, though, were a pair of injuries.
On a play in the sixth inning, Toal attempted to get back to first, but was doubled off and injured his knee in the process.
In the following half inning, Ross gave chase on a ball laced to left center and came up favoring his leg.
Toal's looks to be more serious, but Ross will also miss time.
"Tanner Toal, I'm not sure," Golloway said. "They're going to do an MRI, but it didn't seem very good when he was coming off. It seemed like it's going to be a pretty tough one, but we'll find out later on in the day. And then with Erik Ross, I think he's probably going to be two weeks with a hamstring.
"He's had that problem before and he's been hurt every year, matter of fact. So, we gotta make a decision on moving Max White out there or if we go with Ty Taylor, a backup. Freshman Dylan Raper can really run, but [we'll get] the best to fill that spot."
With the loss, OU (11-8) falls to 0-2 in Big 12 Conference play, while Texas (9-8) improves to 2-0.
The two will conclude the series Sunday at 1 p.m.
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